Eltrombopag is approved in order to treat adult patients with:
Chronic ITP: Initiate eltrombopag at 50mg once in a day for most adult and pediatric patients aged 6 years and older, and at 25mg once in a day for pediatric patients aged 1 to 5 years. Dose reductions are required for patients with hepatic impairment and some patients of Asian ancestry. Adjust to maintain the platelet count more than or equal to 50 x 109/L. It is not recommended to exceed eltrombopag 75 mg per day. Chronic Hepatitis C-associated Thrombocytopenia: Initiate eltrombopag at 25 mg once in a day for all patients. Adjust to achieve the target platelet count needed in order to initiate the antiviral therapy. It is not recommended to exceed a daily dose of eltrombopag 100 mg. First-line Severe Aplastic Anemia: Initiate eltrombopag for aplastic anemia once in a day at 2.5 mg/kg (in pediatric patients aged 2-5 years old), 75 mg (pediatric patients aged 6-11 years old), or 150 mg for patients aged 12 years and older concurrently with the standard IST immunosuppressive therapy. Refractory Severe Aplastic Anemia: Initiate at eltrombopag 50 mg once in a day. Reduce the initial dose in those patients who are with hepatic impairment or patients of Asian ancestry. Adjust to maintain the platelet count more than 50 x 109/L. It is not recommended to exceed the eltrombopag 150mg per day. Side Effects: In adult patients with ITP, the most common side effects are:
In pediatric patients age 1 year and older with ITP, the most common side effects are:
In patients with chronic hepatitis C-associated thrombocytopenia, the most common side effects are:
Drug Availability: Supplied as eltrombopag 12.5 mg, eltrombopag 25 mg, eltrombopag 50 mg, and eltrombopag 75 mg tablets, and is available as an oral suspension in 12.5 mg and 25 mg packets of powder for reconstitution. Storage: Store eltrombopag tablets at room temperature between 68°F-77°F (20°C-25°C). Keep eltrombopag in the bottle given to you. Store eltrombopag for oral suspension at room temperature between 68°F-77°F (20°C -25°C). After mixing, eltrombopag should be taken right away but may be stored for no more than 30 minutes between 68°F-77°F (20°C-25°C). Throw away (discard) the mixture in case it is not used within 30 minutes. FAQ's What is eltrombopag Olamine? Eltrombopag Olamine specifically is the orally active ethanolamine salt of eltrombopag, a small-molecule, nonpeptide thrombopoietin receptor agonist with megakaryopoiesis stimulating activity. Is Eltrombopag an immunosuppressant? Eltrombopag, a thrombopoietin-receptor agonist, is added to the standard immunosuppressive therapy for patients with the previously untreated severe aplastic anemia. What is thrombocytopenia? Thrombocytopenia mainly is a medical term that means the blood does not contain the enough platelets, which are crucial for blood clotting. Several patients with the infection of hepatitis C have this condition, which may mean they are not able to take some of the drugs they need in order to treat hepatitis C, such as interferon. Is ITP a serious disease? In major cases, the condition ITP isn't serious or life-threatening. Acute ITP in children often resolves within 6 months or less. Chronic ITP may last for several years. Individuals can live for decades with this condition, even those with the severe cases.
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