Chronic myeloid leukemia also can be addressed as CML. It is specifically a kind of clonal myeloproliferative disorder driven by the oncogenic tyrosine kinase BCR-ABL. The discovery of the TKI (tyrosine kinase inhibitor) imatinib revolutionized for managing patients with the Chronic Myeloid Leukemia. However, imatinib may have a significant adverse reactions, and is not much effective in all the patients. With the development of the second-generation (dasatinib and nilotinib) as well as third-generation (ponatinib) TKIs (tyrosine kinase inhibitors) sought to address the issue of the imatinib-resistance and -intolerance and furthermore, in order to determine if all these agents are quite superior to the imatinib. Dasatinib, mainly a multitargeted inhibitor, is quite effective and useful against the most BCR-ABL kinase domain mutations resistant to the imatinib and able to induce deeper and rapidly molecular responses.
FDA-approved indication: Dasatinib manufactured by Bristol-Myers Squibb and marketed as Sprycel, is a second-generation, oral, small molecule multitargeted inhibitor. Sprycel, specifically is a kinase inhibitor recommended for the treatment of: ● Adult patients who are newly diagnosed with the Ph+ (Philadelphia chromosome-positive) CML in the chronic phase. ● Adult patients who are carrying accelerated, chronic, myeloid or the lymphoid blast phase Ph+ CML with the resistance or with the intolerance before the therapy including imatinib. ● Adult patients with the Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL) with resistance or intolerance before therapy. ● Pediatric patients 12 month of age and older with the Ph+ CML in the chronic phase. ● Pediatric patients 12 month of age and older with the newly diagnosed Ph+ ALL together with the chemotherapy. Side Effects: The most commonly reported side effects of this drug include: ● fever ● infection ● suppression of the bone marrow ● headache ● hemorrhage (bleeding) ● pleural effusion ● dyspnea (difficulty breathing) ● diarrhea ● vomiting ● nausea (feeling sick) ● abdominal pain (belly ache) ● skin rash ● musculoskeletal pain ● tiredness ● swelling in arms and legs. There are currently 5 TKIs available for CML: ● Imatinib (Gleevec) ● Dasatinib (Sprycel) ● Nilotinib (Tasigna) ● Bosutinib (Bosulif) ● Ponatinib (Iclusig) Dosage: Dasatinib should be administered orally, with or without a meal. Dasatinib tablets should not be crushed or cut. Patients with the Chronic phase CML should take 100 mg once daily and patients with the Accelerated phase CML, myeloid or lymphoid blast phase CML, or Ph+ ALL should take 140 mg once daily. Dosage forms and strength: Dasatinib comes in the form of tablets. The existing strength of this drug are as follows: ● Dasatinib 20 mg ● Dasatinib 50 mg ● Dasatinib 70 mg ● Dasatinib 80 mg ● Dasatinib 100 mg ● Dasatinib 140 mg Is dasatinib a chemo drug? Sprycel is the innovator/trade name for the generic chemotherapy drug dasatinib 20 mg . In a few circumstances healthcare providers may recommend the trade name sprycel cml when referring to the generic Dasatinib. Is dasatinib an immunosuppressant? Dasatinib is a targeted therapy, and mainly exerts an immunosuppressive effect on the CD8+ T cells specific for the viral and leukemia antigens. It functions not just only as an anti-neoplastic in Chronic Myeloid Leukemia but can also act as an immunosuppressive agent. List of Chronic Myeloid Leukemia medication: The below mentioned list of medicines are in some how related to, or used in order to treat CML condition. ● Hydrea (hydroxyurea) ● Iclusig (ponatinib) ● Agrylin (anagrelide) ● cyclophosphamid ● Myleran (busulfan) ● Synribo (omacetaxine) ● peginterferon alfa-2b ● fludarabinefludarabine Note: In order to explore more about above mentioned any drug, please see full prescribing information. Before starting treatment with any drug, consult your doctor. Read - New Treatments of Psoriatic Arthritis Difference Between CLL and SLL
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